Progesterone supplementation

Do not take if you are allergic to peanut oil.

What is progesterone?

It is a hormone secreted from the corpus luteum of the ovary during the second half of the menstrual cycle. Luteinizing hormone (LH) helps make and secrete progesterone from the corpus luteum. It is secreted just before ovulation from the follicle(s) that will release an egg. It helps the uterus accept and keep a pregnancy.

Progesterone therapy can be used to replace or supplement the natural hormone. It can cause changes in the uterine lining like a natural menstrual cycle.

How do I take progesterone?

The day after your insemination or ovulation, you will start taking progesterone vaginally. You will use 1 capsule 2 times each day for 14 days. Take a home pregnancy test and call 1-563-355-2244 with your results after 14 days.

  • Progesterone may delay the start of your period if you are not pregnant. 
  • Keep taking the progesterone until your ultrasound if the pregnancy test is positive.

You do not have to lie down after putting Prometrium® in the vagina. You may want to wear a panty liner for comfort.

What are the risks of progesterone supplementation?

The risk of taking it early in pregnancy and having a baby with birth defects is not totally known. Studies are showing the risks would be small if there are any at all.

What are the side effects of progesterone supplementation?

  • Spotting or bleeding
  • Changes in menstrual flow
  • Swelling
  • Mood changes
  • Weight gain or loss
  • Headache
  • Vaginal irritation

Talk with your nurse or doctor about any concerns.

Last reviewed: 
April 2021

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