Gastrointestinal Cancer Risk and Prevention

Our goal is to increase awareness surrounding genetic factors in malignancies of the digestive system. Recent scientific advances in this field enable us to identify more cases and to have a more significant impact on a patient’s treatment plan.

University of Iowa Difference

  • We offer risk assessment and gastrointestinal cancer advanced prevention and screening options. 
  • We focus on evaluation of genetic and family history of gastrointestinal malignancies and tailor personalized prevention and screening programs. 
  • We consult patients with diagnosed gastrointestinal cancer predisposition syndromes in regard to their personal risk and need for cancer prevention and screening. 
  • We coordinate care of patients with diagnosed gastrointestinal cancer predisposition syndromes. 

Why Choose Holden for Your Care?

Patients of Holden Cancer Center benefit from a team-based approach that puts each patient at the center. At Holden, experts in specific cancer types—including a genetic counselor certified and specializing in cancer genetic counseling—is part of this team.

Holden patients also benefit from medical advances that take into account an individual’s tumor, genes, environment, and lifestyle to diagnose and treat their specific types of cancer. Known as personalized, or precision medicine, this highly specialized approach is part of Holden’s commitment to providing life-changing medical treatments and care.

Who Will Benefit From Our Service?

Patients with a personal of family history of:

  • Multiple colon, stomach, and small bowel polyps 
  • Colorectal or gastric cancer before the age of 50
  • Colorectal cancer at any age with a personal/family history of colorectal or gynecological cancers 
  • Gastric adenocarcinoma at any age with a personal or family history of breast cancer
  • Pancreatic cancer at any age with family history of other cancers  
  • Incidentally found mutation predisposing to gastrointestinal malignancy

Families who have a diagnosis of any of the following cancer predisposition syndromes:

  • Familial adenomatous polyposis (FAP)
  • MUTYH associated polyposis (MAP)
  • Polymerase proofreading associated polyposis (PPAP)
  • Peutz-Jeghers syndrome
  • Juvenile polyposis zyndrome
  • PTEN tumor hamartoma syndrome (Cowden Syndrome)
  • Hereditary mixed polyposis syndrome
  • Hereditary non-polyposis colorectal cancer (HNPCC)
  • Lynch syndrome
  • Familial colorectal cancer type X
  • Hyperplastic polyposis/serrated polyposis
  • Familial colorectal cancer
  • Hereditary diffuse gastric cancer
  • Hereditary pancreatitis
  • Li-Fraumeni syndrome

Our Services Include:

  • Gastrointestinal cancer risk assessment and genetic testing
  • Cancer prevention counseling and strategies
  • Endoscopic cancer screening and surveillance, including esophagogastroduodenoscopy (EGD), duodenoscopy, colonoscopy, double balloon enteroscopy, small bowel capsule endoscopy and endoscopic ultrasound (EUS)
  • Enrollment in ongoing studies of cancer chemoprevention and novel screening strategies
  • Cancer prevention and screening in patients with inflammatory bowel disease 
  • Pancreatic cancer screening for high-risk patients

Care Team