Rare Kidney Diseases Clinic

The University of Iowa’s Rare Renal Disease and Renal Genetics Clinic is a multi-disciplinary clinic whose purpose is to serve the Iowa community as well as physicians throughout the US and abroad in the evaluation and management of rare renal diseases in the adult and pediatric patient. This clinic has a national reputation in complement mediated renal diseases, such as atypical hemolytic uremic syndrome and the C3 glomerulopathies including dense deposit disease. The clinical leader for the complement clinic is Dr. Carla Nester with genetic screening, functional complement assays and molecular diagnosis provided by Dr. Richard Smith and the Molecular Otolaryngology and Renal Research Laboratory. The clinical leaders for other genetic renal diseases are Dr. Christie Thomas, whose interests include Fabry’s disease, Alport syndrome, cystic kidney disease, inherited electrolyte disorders and the evaluation of other genetic renal diseases presenting in the adult and Dr. Patrick Brophy with an expertise in congenital diseases of the kidney in children.

Kinds of services

  • To serve as a national referral center for children and adults with atypical hemolytic uremic syndrome, dense deposit disease and C3 glomerulopathy
  • To consolidate the evaluation and management of rare inherited renal diseases such as Fabry’s disease and nephronophthisis into one clinic
  • To coordinate appropriate consultative services for patients with multisystem  manifestations and to direct appropriate genetic and complement function testing through the Molecular Otorhinolaryngology and Renal Laboratories and other National and International molecular diagnostic laboratories
  • To offer diagnostic consultation for patients with uncharacterized inherited renal disease
  • To offer consultation and management for inherited tubulopathies e.g. renal tubular acidosis, hypokalemic syndromes
  • To offer diagnostic evaluation for patients with familial renal stone disease
  • To offer screening for family members at risk for any inherited renal disease
  • To evaluate potential kidney donors at risk for genetic renal disease

Diseases with special focus

  • Atypical hemolytic uremic syndrome (aHUS)
  • Dense Deposit Disease (DDD also sometimes called Type 2 MPGN)
  • C3 glomerulopathy (C3GN)
  • Fabry Disease
  • Alport syndrome
  • Juvenile Nephronophthisis
  • Medullary Cystic Kidney Disease
  • Renal Cysts and Diabetes
  • Branchio-oto-renal syndrome
  • Bartter syndrome
  • Renal tubular acidosis

Care Team

Physician, Internal Medicine

Physician, Otolaryngology - Head and Neck Surgery