Progesterone supplementation

Do not take if you are allergic to peanut oil.

What is progesterone?

Progesterone is a hormone your body makes after your ovary releases an egg during your menstrual cycle. It helps your uterus get ready for a pregnancy to implant and grow. 

Progesterone therapy can be used to replace or supplement the natural hormone. It can change the uterine lining like a natural menstrual cycle.

How do I take it?

Use your fingers to place the gel capsule about 2 to 3 inches into the vagina, like putting in a tampon. 

• Start using progesterone 3 days after a positive ovulation predictor kit (OPK) or 2 days after insemination. 
• Use 1 capsule 2 times each day until 2 weeks after ovulation. 

After 2 weeks, take a home pregnancy test and call the clinic with your results.

• Progesterone may delay the start of your period, even if you are not pregnant. 
• If your pregnancy test is positive, keep taking progesterone until your ultrasound. Your provider will tell you when you can stop using it. 

You do not have to lie down after putting progesterone in your vagina.  You may want to wear a panty liner for comfort.

What are the risks of progesterone supplementation?

The risk of taking it early in pregnancy and having a baby with birth defects is not totally known. Studies are showing the risks would be small if there are any at all.

What are the risks?

• Spotting or bleeding
• Changes in menstrual flow
• Swelling
• Mood changes
• Weight gain or loss
• Headache
• Vaginal irritation

Talk with your nurse or doctor about any concerns.