Laboratory Services: DeGowin Blood Center

Transfusion Service

The blood bank processes all donated blood into components that are acceptable for transfusion.  They also perform compatibility testing, antibody identification, transfusion reaction evaluations and provide specialized blood components for transfusion.  Specialized components include irradiated products, granulocytes, washed red cells, washed platelets, and reconstituted blood.  The lab is able to identify compatible blood through a variety of complex testing procedures that determine the specificity of antibodies that a patient may have.  The blood bank is registered with the Food and Drug Administration (FDA) and accredited by AABB and the Collage of Clinical Pathologists (CAP).

Tissue and Cellular Therapies

University of Iowa Hospitals & Clinics DeGowin Blood Center’s Tissue and Cellular Therapies is comprised of two distinct sections. The Hematopoietic Progenitor Cell Laboratory provides processing and cryopreservation, and distribution of cord blood, peripheral blood and bone marrow cells primarily for patients receiving either autologous or allogeneic hematopoietic stem cell transplantation. The Tissue Bank manages human tissue required for many surgical procedures and provides traceability of the tissue from source to implantation.

Hematopoietic Progenitor Cell Laboratory (HPC Lab)

The HPC Lab provides services primarily for the Adult and Pediatric Stem Cell Transplant and Cellular Therapy Programs in which approximately 200 transplants are performed each year. The HPC Lab also prepares cellular therapy products collected at UI Hospitals & Clinics, as a NMDP collection center, for transport to other institutions. The HPC Lab participates in both institutional and multi-center study protocols. Processing performed in this laboratory is done under cGMP and cGTP guidelines to provide high quality, viable, and sterile products that help ensure timely engraftment or treatment.

Procedures performed in the HPC Lab include:

  • Product evaluation (cell counts, cell viability, volume, sterility assessment)
  • Volume reduction
  • Red blood cell reduction
  • CD34 cell selection
  • Cryopreservation
  • Thawing for infusion (may include washing)
  • Product preparation for transport to other institutions
  • Product distribution

The DeGowin Blood Center Tissue and Cellular Therapies Hematopoietic Progenitor Cell Laboratory is accredited by the Foundation for Accreditation of Cellular Therapy (FACT) and is registered with the Food and Drug Administration (FDA). It is also accredited with the National Marrow Donor Program (NMDP).

Tissue Bank

The Tissue Bank maintains an inventory of a variety of human tissue required for surgical procedures such as skin grafting, bone and joint reconstruction, cornea transplant, and cardiac valve replacement, performed at the UI Hospitals & Clinics. The Tissue Bank is also responsible for ordering tissue from vendors, storing the tissue under appropriate conditions, tracking the tissue to final disposition, and managing any tissue recalls or product complaints that may arise.  In addition the Tissue Bank stores organ donor vessels as well as autologous bone, parathyroid, and skin for the surgical services.

The Tissue Bank is accredited by AABB and the College of American Pathologists (CAP).