Doxy-PEP is short for doxycycline post-exposure prophylaxis. It is a medicine you can take after unprotected sex to help lower your chance of getting syphilis or chlamydia.
Doxy-PEP is meant to be an emergency back-up plan. It does not replace using condoms or other barrier methods during sex. Doxy-PEP does not protect against other STIs, such as HIV, herpes, or trichomonas.
How does Doxy-PEP work?
A health care provider will prescribe Doxy-PEP for you to keep on-hand in case you need it. If you have unprotected oral, anal, or vaginal sex, you take a one-time dose of doxycycline 200 milligrams (mg) as soon as you can.
Doxy-PEP works best when taken within 72 hours (3 days) after sex.
Doxycycline pills come in different strengths, so be sure that you take the number of pills that your provider prescribed.
If you are unsure, ask your pharmacist.
Doxy-PEP does not treat an infection you already have. After taking Doxy-PEP, make an appointment or go to a walk-in clinic for STI testing and treatment.
Who should take Doxy-PEP?
Doxy-PEP works best for people who are at higher risk of STIs. You may be at higher risk if you:
Often have sex without condoms or other barriers.
Have several sexual partners (such as hook-ups, open relationships, or meeting partners through apps)
Have had a positive STI test in the last year (12 months).
Have had multiple STIs in your lifetime or have had the same STI more than one time.
What are the side effects and risks of Doxy-PEP?
Doxycycline is a common and very safe antibiotic. The most common side effects are:
Mild diarrhea
Skin becoming more sensitive to the sun
Rare side effects (usually with long-term use):
Liver problems
Rash
Fungal infections
These side effects have not been reported in people using doxycycline for Doxy-PEP. There may be a risk of bacteria becoming more resistant to antibiotics, but this has not been proven.
Do I need any other tests to get a Doxy-PEP prescription?
No, there are no tests that you need to do to get a Doxy-PEP prescription. Your medical provider may recommend STI testing, such as for chlamydia, gonorrhea, syphilis, and HIV, before starting Doxy-PEP and again every 3 to 6 months while you are using it.
Where can I get Doxy-PEP?
University of Iowa Family Medicine providers can prescribe Doxy-PEP and help with other primary care and sexual health needs. Schedule an appointment through MyChart, online, or by calling 319-384-7222.
University of Iowa students can schedule an appointment with Student Health and Wellness by submitting an appointment request on MyChart or by calling 319-335-8394.
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