Methotrexate works by altering the immune system to decrease the activity of immune cells called T lymphocytes. It is a pill that you take by mouth or an injection (shot) that is done one time a week. It can take three to six months for your skin to improve.
Side effects of methotrexate
Fatigue (feeling very tired)
Cold or flu-like symptoms
Low blood counts
Higher risk of infections
Rare but serious side effects of methotrexate
Lung disease called pneumonitis
Call your doctor if you have any of the above side effects.
Take an over-the-counter folic acid supplement on the six days of the week that you do not take methotrexate. The folic acid will help stop many of the above side-effects.